Based on these facts, the starting lineup of the Colts should get LOTS of 4th quarter rest.

Indianapolis (6-0) at Houston (0-5)
* The Colts have won all six meetings by a combined score of 164-72. The Colts have outscored the Texans 41-0 in the first quarter of those contests.
* The Colts have won 13 of their last 15 division games, including the last five. The last time the Colts won six straight division games was back in 1976-77.
* Indy has outscored its opponents 71-12 in the second and third quarters combined this season.
* Colts’ RB Edgerrin James has averaged 116.3 rushing yards in his last four games vs. Houston, including three 100+ yard performances.
* Indy WR Reggie Wayne has five touchdown receptions in six career games vs. the Texans.
* Colts’ DE Robert Mathis leads the league with seven sacks, including at least one in each game this season.
* Houston is 0-5 and its next five opponents are a combined 21-7, including two games against the 6-0 Colts.
* The Texans have lost their last eight games when allowing their opponents to gain at least 300 yards of offense.
* Houston RB Domanick Davis is averaging 155.8 scrimmage yards with seven touchdowns in four career games vs. the Colts. Davis has rushed for at least 98 yards in each contest.
* Houston QB David Carr has thrown just one interception in his last four games.